This longitudinal single-cell transcriptome atlas examines global changes amongst murine mammary gland fibroblasts during normal development and oncogenesis across seven different states, revealing a ...

"The stroma is considered a key component in the aggressive nature of pancreatic cancer, as it interacts with tumor cells, protects them, and hinders the action of drugs. Moreover, stromal cells, ...

This discovery is important because it reveals a hidden layer of how pancreatic cancer resists treatment. If Galectin-1 inside fibroblast nuclei can turn these cells into active supporters of the ...

"We need to find new inhibitors that work inside fibroblasts, not just on the protein they secrete," she adds. To carry out the study, researchers worked with tissue samples from pancreatic cancer ...

Activated fibroblasts promote tumor growth and spread, while also conferring resistance to treatments. This may be one of the reasons behind the high aggressiveness of pancreatic cancer ...

Apr. 9, 2025 — Scientists have developed a new method for identifying and classifying pancreatic cancer cell subtypes based on sugars found on the outside of cancer cells. These sugars ...

The pancreas is among the most important organs in your body, making substances that control your blood sugar and help your body digest foods. While surgery to remove the whole pancreas is rarely done ...

Now, a groundbreaking international study has found a surprising new way these fibroblasts promote pancreatic cancer—through a protein called Galectin-1. Researchers from the Hospital del Mar ...

"We need to find new inhibitors that work inside fibroblasts, not just on the protein they secrete," she adds. To carry out the study, researchers worked with tissue samples from pancreatic cancer ...