Autophagic flux was examined by the buildup of p62 or ubiquitinated organelle protein. Endolysosomal structures were examined by electron microscopy. Cell-specific autophagy was evaluated by ...

Over time, the disease can also affect memory and lead to dementia. A similar condition called Lewy Body Dementia (LBD), ...

Autophagy in B cells has been less studied ... UK). Intracellular staining for p62 was performed following fixation and permeabilisation with BD Fix/Perm kit I (BD Biosciences). In human experiments, ...

We also demonstrate that the autophagic target SQSTM1/p62 is decreased in SOD1-G93A microglia after a short stimulation of P2X7, but increased after a sustained challenge. These effects are prevented ...

This Patent Highlight integrates bifunctional degraders, leveraging autophagy via p62, and substituted oxazolone compounds targeting IKZF1–4 transcription factors. These compounds demonstrate ...

In present study, we sought to gain a knowledge on the level of autophagy proteins (beclin1, p62/SQSTM1) in FD patients. Methods Ten newly diagnosed FD patients and 10 age- and sex-matched ...

This study presents a valuable finding on the alterations in the autophagic-lysosomal pathway in a Huntington's disease model. The evidence supporting the claims of the authors is solid. However, the ...