Metoprolol is used for phenotyping of cytochrome P450 (CYP) 2D6, a CYP isoform considered not to be inducible by inducers of the CYP2C, CYP2B ... metoprolol increased by a factor of 6 in HepaRG cells ...

A complementary analysis of the clinical PK-DDI studies by Huth et al. evaluated via a hybrid bottom-up and top-down strategy the effect of DDI inducers or inhibitors of the CYP3A and CYP2C9 enzymes ...

Imatinib mesylate, a protein tyrosine kinase inhibitor, can induce caspase-independent ... expressed by glioblastoma cells increased the sensitivity to inducers of cell death 87.

A more recent randomized, double-blind, placebo-controlled clinical trial [22] compared the efficacy and safety of St. John's wort to placebo in outpatients with major depression, using ...

Expert Rev Endocrinol Metab. 2010;5(5):653-662.