Elinogrel (PRT060128 or PRT128) (Figure 3) is a direct-acting, reversible P2Y 12 antagonist (Figure 5) that can be administered both intravenously and orally. This unique dual formulation provides ...

P2Y 12 inhibitor‐based single antiplatelet therapy (SAPT) after drug‐eluting stent implantation reduces major bleeding without increasing the risk of major adverse cardiovascular and cerebral events ...

Biogen Inc. has disclosed uracil nucleotide/cysteinyl leukotriene receptor (GPR17; P2Y-Like) antagonists with improved brain penetration reported to be useful for the treatment of multiple sclerosis.

近年来，嘌呤能信号通路相关药物的研究取得了令人瞩目的进展。嘌呤能信号通路涉及多种细胞活动的调节，其中 P2X、P2Y 和腺苷受体，以及介导核苷酸顺序去磷酸化的外核苷酸酶（ecto - nucleotidases）起着关键作用。 目前，许多疾病的治疗仍面临困境。以骨关节 ...

Purinergic signaling encompasses four adenosine receptors, eight P2Y receptors that respond to various extracellular nucleotides, and trimeric P2X receptors that respond mainly to ATP. Each organ and ...

此前的研究虽发现 COVID-19 与广泛的炎症变化有关，且小胶质细胞（中枢神经系统实质中的主要炎症细胞）在患者大脑中出现形态转变和炎症特征，但 SARS-CoV-2 感染、中枢神经系统炎症和小胶质细胞表型变化之间的具体联系却尚不明确。正是在这样的背景下，研究人员开展了此次意义重大的研究，试图揭开 COVID-19 相关神经异常机制的神秘面纱。

The key targets in the Coronary Artery Disease (CAD) (Ischemic Heart Disease) pipeline products market include P2Y Purinoceptor 12, Platelet Glycoprotein VI, and Hepatocyte Growth Factor. The key ...