Oncogene-induced senescence is a mechanism of tumor suppression that restricts the progression of benign tumors. Important advances have been made toward elucidating the mechanisms that regulate ...

Skeptics of the idea that oncogene-induced cell senescence is a potential anticancer mechanism have correctly pointed out the many differences between in vitro and in vivo conditions. 46 For ...

PDH, a crucial mediator of oncogene-induced senescence PDH is an enzyme complex located at the mitochondrial matrix regulated by phosphorylation (catalysed by PDH-inhibitory kinase) and ...

Activated oncogenes are able to induce senescence, and recent findings have suggested that oncogene-induced senescence (OIS) could play a key role in future cancer therapy. Researchers have now ...

Activated oncogenes are able to induce senescence, and recent findings have suggested that oncogene-induced senescence (OIS) could play a key role in future cancer therapy. Researchers have now ...

[button url="http://chem.colorado.edu/" color="blue"]Department of Chemistry and Biochemistry[/button] [button url="www.colorado.edu" color="blue"]University of ...

Michaloglou et al., "BRAFE600-associated senescence-like cell cycle arrest of human naevi," Nature, 436:720-4, 2005. (Cited in 92 papers) The finding: Two groups of researchers from the Netherlands ...

“What was unexpected was just the fact that cancer cells had retained the ability to undergo senescence at all,” says Dean Felsher, M.D., Ph.D., associate professor of medicine and patholog ...

These mutated cells first expand but soon thereafter enter oncogene-induced senescence (OIS). The end of this process is a circumscribed lesion with relatively higher numbers of senescent melanocytes.