Skeptics of the idea that oncogene-induced cell senescence is a potential anticancer mechanism have correctly pointed out the many differences between in vitro and in vivo conditions. 46 For ...

Oncogene-induced cellular senescence (OIS) is a complex program that is triggered in response to aberrant activation of oncogenic signaling. Initially, OIS was thought to be a barrier to malignant ...

PDH, a crucial mediator of oncogene-induced senescence PDH is an enzyme complex located at the mitochondrial matrix regulated by phosphorylation (catalysed by PDH-inhibitory kinase) and ...

Activated oncogenes are able to induce senescence, and recent findings have suggested that oncogene-induced senescence (OIS) could play a key role in future cancer therapy. Researchers have now ...

Article #17-21160: "Naked mole rats can undergo developmental, oncogene-induced and DNA damage-induced cellular senescence," by Yang Zhao et al.

oncogenes signal strong cell-growth arrest. Until this paper, an in vivo correlate had not been demonstrated. Moreover, telomere shortening previously was assumed to be the mechanism. The researchers ...

These mutated cells first expand but soon thereafter enter oncogene-induced senescence (OIS). The end of this process is a circumscribed lesion with relatively higher numbers of senescent melanocytes.

Activated oncogenes are able to induce senescence, and recent findings have suggested that oncogene-induced senescence (OIS) could play a key role in future cancer therapy. Researchers have now ...