During oncogene-induced senescence there are striking changes in the organisation of heterochromatin in the nucleus. This is accompanied by activation of a pro-inflammatory gene expression programme – ...

1Cancer Research Centre of Lyon, INSERM U1052, CNRS UMR5286, Claude Bernard University, Lyon, France. 2Department of Geriatrics, Ruijin Hospital, School of Medicine ...

Unlike replicative senescence, oncogene-induced senescence caused heterochromatin-body formation. Major Finding: Unlike replicative senescence, oncogene-induced senescence caused heterochromatin-body ...

Oncogene-induced cellular senescence (OIS) is a complex program that is triggered in response to aberrant activation of oncogenic signaling. Initially, OIS was thought to be a barrier to malignant ...

Here, we characterize cellular senescence in the NMR. We find that naked mole rat cells undergo three major types of cellular senescence: developmental, oncogene-induced, and DNA damage-induced.

† Biomolecular Mass Spectrometry and Proteomics, Utrecht Institute for Pharmaceutical Sciences and Bijvoet Center for Biomolecular Research, Utrecht University, Padualaan 8, 3584 CH Utrecht, The ...

Institute of Biochemistry and Molecular Medicine, National Council for Scientific and Technological Research, Department of Pathophysiology, School of Pharmacy and Biochemistry, University of Buenos ...

Growing evidence supports a central role of the oncogenic BRAF V600E mutation in histiocytosis pathogenesis, and suggests oncogene-induced senescence (OIS), a major protective mechanism against ...

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