Oncogene activation also causes DDR activation and cellular senescence. Oncogene-induced DNA damage is caused by altered DNA replication, and oncogene-induced senescence is a barrier to cancer.

Figure 1: PML is required for Ras-induced senescence in primary cells. Figure 5: Colocalization of PML, CBP and p53 after expression of PML or RasV12. Infection of MEFs was carried out as described 1.

Temperatures above 35°C can cause irreversible damage, including premature leaf senescence. Heat-induced leaf senescence reduces both the forage yield and turf quality. As global temperatures ...