Airport screening in the U.S. detected the new variant in travelers arriving in California, Washington state, Virginia and ...

Different coatings for glass slides are being developed that encourage maximal preservation of antigen structure and antibody binding, while trying to minimize nonspecific (background) antibody ...

Conformational diversity of foreign antigens is an equally important and poorly understood variable. Important vaccine targets are often disordered or surrounded by flexible loops such as the ...

In cancer immunotherapy, robust and efficient activation of cytotoxic CD8+ T cell immune responses is a promising, but challenging task. Dendritic cells (DCs) are well-known professional antigen ...

Bispecific T cell engagers (TcEs) that are able to simultaneously bind to epitopes on cancer cells and T cells are a versatile, highly potent, and economical immunotherapeutic tool ().TcEs are ...

The types of the immune responses generated against an antigen are determined by the intracellular fate of the antigen. Endogenous antigens are processed in the cytoplasm and initiate cytotoxic T ...

Background: Approximately 30% of pts with R/R LBCL who relapse after CAR T-cell therapy experience CD19 antigen escape (Spiegel et al. Blood. 2021).KITE-363 is a bicistronic, autologous CAR T-cell ...

A phase 1 study of intracerebroventricular (ICV) delivery of bivalent chimeric antigen receptor (CAR) T-cells targeting EGFR and IL13Ra2 in patients with recurrent glioblastoma (rGBM). Authors : ...