Mitoribosomes are present in the mitochondria of all eukaryotic cells. Their function is to allow the translation of mitochondrial mRNA that exclusively encodes components of the oxidative ...

Mitochondrial ribosomes, or mitoribosomes, play a crucial role in synthesizing proteins that are essential for cellular energy production through oxidative phosphorylation (OXPHOS). These ...

The TP53 gene is a gene that is mutated in many cancers. It is the most common gene mutation found in cancer cells. A tumor-suppressor gene, TP53 codes for a protein that inhibits the development and ...

This complex process, known as gene expression, determines which proteins we make and whether we make them in the correct amounts, crucial work given that proteins play a role in virtually every a ...

1. 澳大利亚纽卡斯尔大学的研究发现，抑制线粒体氧化磷酸化(oxphos)能抑制糖酵解功能健全的结直肠癌(crc)细胞的增殖和致瘤性。 2. 研究结果显示 ...

In this report, the authors made use of a murine cell life derived from a MYC-driven liver cancer to investigate the gene expression changes that accompany the switch from normoxic to hypoxia ...

The same is now possible in gene editing. Rather than employ separate tools for editing genes and regulating their expression, these distinct goals can now be combined into a single tool that can ...

Currently, there are several therapies that target cell signaling networks in PC. However, PC is a “cold tumor” with a unique immunosuppressive tumor microenvironment (poor effector T cell ...

Furthermore, as the only lactate-related gene among the nine key prognostic risk genes, myeloperoxidase (MPO) was identified as a key factor that mediates lactate production in vitro and in vivo ...

Objective Patients with increased PD-L1 + host cells in tumours are more potent to benefit from antiprogrammed death-1/programmed death ligand-1 (PD-L1) treatment, but the underlying mechanism is ...