In this work, we studied the reaction of 2-chloro-5-nitro pyrimidine (electrophile) with the family of α-nucleophiles depicted in Table 1 (see bottom in Results and Discussion) in aqueous media.

Alpha nucleophiles’ ability to get close to electrophiles – rather than their intramolecular lone pair repulsion – gives them unusual reactivity The origin of the alpha effect, which gives some ...

DNA synthesis reaction. (A) Deprotonation and activation of the primer-end 3′-OH for the nucleophilic attack is hypothesized to be the first step.(B) In the three–Mg 2+-ion catalysis, the first step ...

To determine if there is a general base in the DNA synthesis reaction that deprotonates the nucleophile, we systematically removed potential hydrogen-bond acceptors of the nucleophile, the 3′-OH of ...

The condensation reactions between carbonyl groups (aldehyde, ketone) and N-nucleophiles (primary amine, hydrazide, and aminooxy) undergo spontaneously in physiological conditions, yielding Schiff ...

This unnerving reaction is called contact dermatitis. It can seriously sour your relationship with cosmetics, especially if you’re not sure which product in particular is behind the rash on your ...

JEE Main 2018: Revision notes with important questions for Free radicals and SN1 & SN2 mechanisms. In this article we are going to talk about the SN 1 & SN 2 Reactions, conditions of free radical ...

In S N 2 reactions, the approach of the nucleophile towards the reactive centre of the electrophile leads to the extrusion ... Quaternary stereocentres via an enantioconvergent catalytic SN1 reaction.

1083 Objectives Numerous metal-free cross-coupling reactions of tosylhydrazones with different reaction partners have been recently reported. These building blocks are easily available from carbonyl ...