The structure of the TS (formerly twister sister) ribozyme reveals details about its catalytic mechanism of nucleolytic self-cleavage using a hydrated magnesium ion, and illustrates key ...

We present a crystal structure at 2.3-Å resolution of the recently described nucleolytic ribozyme twister. The RNA adopts a previously uncharacterized compact fold based on a double-pseudoknot ...

Previously, the leading RNA polymerase ribozyme, called R18, could only transcribe RNAs up to 14 bases long (as a frame of reference, R18 itself is about 196 bases long).

Breaker's team found the new ribozyme at one end of the messenger RNA that codes for an amidotransferase enzyme. When the mRNA is translated into protein, the enzyme produced makes glucosamine-6 ...

Important progress for RNA research: A team led by Würzburg chemistry professor Claudia Höbartner has discovered a new ribozyme that can label RNA molecules in living cells.

Directed evolution yields an RNA polymerase ribozyme that can both replicate and transcribe RNA and thus support an RNA world. genprowebdirectory Facebook Linkedin RSS Twitter Youtube ...

For even the smallest ribozyme studied by the researchers, only 48 bases, there are 10,296 total single and double mutants. "With the help of a powerful DNA sequencer at OIST, we generated and then ...

Article #19-14282: "An RNA polymerase ribozyme that synthesizes its own ancestor," by Katrina F. Tjhung, Maxim N. Shokhirev, David P. Horning, and Gerald F. Joyce.

New ribozyme can make RNA molecules accessible for click chemistry in living cells. ScienceDaily . Retrieved April 11, 2025 from www.sciencedaily.com / releases / 2023 / 09 / 230905125007.htm ...

So far, though, efforts to make a self-replicating ribozyme have come up short. Most RNA molecules with this sort of activity have been around 200 bases long and have tended to stall before ...

More precisely: the ribozyme transfers a single methyl group to an exactly defined nitrogen atom of the target RNA. This makes it the first known methyl transferase ribozyme in the world. Accordingly, ...

A SAM analogue-utilizing ribozyme for site-specific RNA alkylation in living cells. Nat Chem. 2023. doi: 10.1038/s41557-023-01320-z. This article has been republished from the following materials.