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Although the involvement of the Notch signaling pathway in its development is recognized, its role in clinical specimens has not been extensively studied. Methods: We analyzed surgically resected ...

André Briend is the 2025 recipient of the John Dirks Canada Gairdner Global Health Award, which recognizes outstanding ...

NOTCH signaling plays a crucial role in tumorigenesis ... Noncanonical signaling involves interactions with other pathways without RBPJ involvement. Read the full story here.

In this work, the mechanism underlying the relationship between the mTOR signaling pathway and orthoflavivirus infection was reviewed from three perspectives: orthoflavivirus structure and life cycle, ...

This manuscript demonstrates that Oct4 overexpression synergizes with Notch inhibition (Rbpj knockout) to promote the conversion of adult murine Müller glia (MG) into bipolar cells. These findings are ...

For this article, Eugene Russo interviewed Mark E. Fortini, an assistant professor of genetics at the University of Pennsylvania, Iva Greenwald, a Howard Hughes Medical Institute investigator and ...

PRNewswire/ - The Gairdner Foundation is pleased to announce the 2025 Canada Gairdner Award laureates, recognizing some o ...