These melanomas often have overactive nitric oxide synthases (NOS), linked to worse outcomes. A study co-led by Srivastava explored how nitrosylation, a modification caused by nitric oxide, affects ...

Nitrosative stress via S-nitrosylation inhibits vascular contractile phenotypic restoration in rats ... 4-carboxamide1-β-D-ribofuranoside (AICAR), N’-nitro-L-arginine-methyl ester hydrochloride ...

A solution of human hemoglobin (100 μM) was incubated with HOCl (100 μM, pH 7.4) at 37 °C for 20 min. The relative extents of chlorination, nitration, and nitrosylation of tyrosine, as well as ...

One of the key mechanisms by which NO exerts its effects is through protein S-nitrosylation. S-Nitrosylation involves the transfer of a nitroso group to cysteine residues, resulting in the formation ...

NMT5 could modify ACE2 at both of the cysteine residues (Cys261 and Cys498), which were susceptible to S-nitrosylation by S-nitrosocysteine (SNOC). ACE2 was successfully S-nitrosylated by SNOC.

Protein S-nitrosylation is the most prominent and widely studied PTM among others. It is the selective but reversible redox-based covalent addition of a NO moiety to the sulfhydryl group of cysteine ...

The protein S-nitrosylation (SNO) is an ubiquitous, redox reversible, post-translational modification of cysteine residues that occurs in presence of excessive oxidative and nitrosative stress (Htet ...

Trx1 can be S-nitrosylated and, in turn, can trans-nitrosylate other proteins. However, the role of Trx1-dependent S-nitrosylation in cardiomyocytes (CMs) is not known. Here, we investigated the role ...

Studies from our lab have shown that elevated GRK2 levels in ischemia-reperfusion (I/R) injury result in a pro-death phenotype. Interestingly, cardio-protection can be inferred via S-nitrosylation of ...

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