These melanomas often have overactive nitric oxide synthases (NOS), linked to worse outcomes. A study co-led by Premiexplored how nitrosylation, a modification caused by nitric oxide, affects the ...

These melanomas often have overactive nitric oxide synthases (NOS), linked to worse outcomes. A study co-led by Srivastava explored how nitrosylation, a modification caused by nitric oxide, affects ...

Protein modification through S-nitrosylation regulates their function. Here, the authors show that S-nitrosylation of EZH2 dampens its methyltransferase activity, inducing cytosolic localization ...

Researchers at Moffitt Cancer Center have discovered that blocking a chemical process called nitrosylation can make aggressive NRAS-mutant melanoma more responsive to treatment. This form of skin ...

Figure 5: RP-HPLC analysis with UV detection of S-nitrosylation products of wild-type (or mutant) decapeptide containing the N-terminal cysteine (or alanine substitution) at residue 399 of the ...

Departments of Pathology and Chemistry, University of Vermont, Burlington, Vermont 05405, and Department of Microbiology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto 860-8556, ...

Major reactive oxygen species (ROS)–producing systems in vascular wall include NADPH (reduced form of nicotinamide adenine dinucleotide phosphate) oxidase, xanthine oxidase, the mitochondrial electron ...

Food-animal breeders are beginning to leverage advances in the fields of genomics and biotechnology to make targeted changes in DNA, called heritable genetic modifications (HGMs), that can be passed ...

A fleet of cloud seeding drones increased rainfall by over 4 per cent across more than 8,000 sq km (3,089 sq miles) in a day, according to the project team led by Li Bin, senior engineer with the ...

The heavy metal (HM) sorption and removal capacity of BC can be enhanced by developing novel biochar nanohybrids (BNHs) that can be produced via surface modification of BC with nanomaterials. Loading ...

Efficacy of a Mobile Health–Based Behavioral Treatment for Lifestyle Modification in Type 2 Diabetes Self-Management: Greenhabit Randomized Controlled Trial J Med Internet Res 2025;27:e58319 doi: ...

Lord Justice William Davis said: "The sentences were intended to give a message to anyone minded to engage in highly dangerous procedures involving body modifications. "That reflected an ...