The cause of Niemann-Pick disease is relatively complicated. People who have this disease inherit one of several genetic defects, resulting in a buildup of sphingomyelin, a type of fat. As the ...

Niemann-Pick type B is caused by a defect in the SMPD1 gene, which results in reduced production of Acid Sphingomyelinase, which causes sphingomyelin to build up in the cells, which in turn ...

Mutations in NPC1 cause Niemann-Pick Type C. Mice lacking NPC1 only in microglia have rampant neuroinflammation ... In their study, first author Lina Dinkel and colleagues found that inactivating Npc1 ...

Zevra to receive a 2025 New Treatment Award for MIPLYFFA™ at the 21st Annual WORLDSymposiumEight abstracts discussing data and clinical ...

Growth factor signalling is a cell signalling pathway that regulates ... into tumour-initiating cells. The role of Niemann-Pick disease type C protein 1 (NPC1) in liver cancer is underexplored.

Takeda’s agreement with Evox covers a preclinical-stage candidate for Niemann-Pick disease type C (NPC ... or ‘vesicles’ that are used by cells to transport molecules between them ...

Jan. 28, 2025 — A team of stem cell scientists have successfully used embryonic stem cell engineering to create a bi-paternal mouse -- a mouse with two male parents -- that lived until adulthood.

Hans Niemann has challenged Magnus Carlsen and Hikaru Nakamura for an over-the-board blitz chess match. Reuters American grandmaster Hans Niemann has challenged World No 1 chess player Magnus Carlsen ...

Privately-held IntraBio's Aqneursa also won FDA approval for the treatment of Niemann-Pick disease type C ... for people with advanced small-cell lung cancer. It is the first and only so ...

Hans Niemann has challenged Arjun Erigaisi and Fabiano Caruana for matches but both are yet to accept the challenge. Image: X / @FIDE_chess American grandmaster Hans Niemann believes that the ...

To enter a human cell, an ebolavirus glycoprotein has to ... helped discover the cholesterol-trafficking protein Niemann-Pick C1 (NPC1) as this critical Ebola entry receptor.