Hyundai Bio’s drug candidate, Xafty, is a new formulation of niclosamide, used for decades to treat infections caused by parasitic worms and, in recent years, proposed as a potential therapy for ...

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Reagents and antibodies used in these studies were as follows: D-galactose, 4,6-diamidino-2-phenylindole (DAPI), JAK2 inhibitor AG490, STAT3 inhibitor niclosamide, and a mouse monoclonal antibody (mAb ...

The most stable drug molecules docked with DUSP6 and TAB2 are tanespimycin and niclosamide, with binding energies of −5.67 and −9.26 kcal/mol, respectively; the most stable drug binding to 3CLpro is ...

随后，刘教授提出了目前研究现状下，还尚未回答和解决的科学问题。为了进一步探究这些问题，刘教授进一步发现了 表达 CLIC1 的外泌体与 DCs 细胞膜上 TMEM16F 的相互作用，在利用 Niclosamide 阻断 TMEM16F-CLIC1 相互作用后，缓解了小鼠心脏移植后的排斥反应。