In the mature nervous system, DNA double-strand breaks (DSBs) are mainly repaired by non-homologous end-joining (NHEJ) pathways. It has been demonstrated that NHEJ deficiencies are associated with ...

Repair of this damage utilizes either single-strand break (SSB) or double-strand break (DSB) repair pathways. We and others have previously shown that inhibition of poly (ADP) ribose polymerase-1 ...

Scale bar, 20 µm. Figure S2. Examination of the NHEJ pathway activity in Bend2 Δ11/ y mice (A) Representative images of Ku70 expression pattern in wild type and Bend2 Δ11/y testis. Scale bar, 40 μm.

Janus kinase/signal transduction and transcription activation (JAK/STAT) pathways were originally thought to be intracellular signaling pathways that mediate cytokine signals in mammals. Existing ...

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Microglia are brain-resident macrophages playing pivotal roles in CNS development and homeostasis. Yet, the cellular and molecular basis governing microglia maintenance ...

目前，精准操控这些染色体重排面临着巨大挑战。传统的基因组编辑技术在寻找匹配序列时困难重重，而 CRISPR-Cas9 系统虽能引入靶向 DNA 双链断裂（DSB），但通过非同源末端连接（NHEJ）连接远端 DSB 的效率极低，替代方法如引导编辑（prime editing）虽能提高准确性 ...

FILE - Adnan Syed and his mother Shamim Rahman talk with reporters as they arrive at Maryland's Supreme Court in Annapolis, Md., Thursday, Oct. 5, 2023. (AP Photo/Susan Walsh, File) ...