This article considers neuraminidase inhibitors, which are active against influenza virus and are crucial to planning for an influenza pandemic from a new influenza virus of any origin, including a ...

Influenza continues to pose a significant global health burden, with seasonal outbreaks causing substantial morbidity and ...

Development of novel influenza neuraminidase inhibitors is critical for preparedness against influenza outbreaks. Knowledge of the neuraminidase enzymatic mechanism and transition-state analogue ...

As 2017 closes out, national influenza activity is increasing. All 10 US regions characterized by the CDC have reported elevated outpatient influenza-like illness, i.e., above the national or ...

Influenza A (H5N1) virus causes severe disease in humans and poses an unprecedented pandemic threat. 1–3 The neuraminidase inhibitor oseltamivir constitutes an important treatment option, and ...

Cidara Therapeutics, a US biotech leveraging its Cloudbreak platform for next‑generation antivirals, saw its stock more than ...

The study identifies four mutations in neuraminidase of human-like H5N1 influenza viruses that act synergistically to increase viral replication and induce moderate virulence in mammals, while ...

Background: Safe and effective antiviral agents are needed to prevent infection with influenza A and B virus. Oseltamivir (GS4104), which can be administered orally, is the prodrug of GS4071, a ...

Its full scientific name is avian influenza A(H5N1), so it contains hemagglutinin 5 and neuraminidase 1. Bird flu primarily affects birds, as per the name, but has adapted to infect cows and can ...

Influenza vaccine development has largely focused on the hemagglutinin, but the other major surface antigen, the neuraminidase, has reemerged as a potential target for universal vaccines,” the ...

InDevR Inc. announced product release of the first ever commercial reagent kit designed explicitly for assessment of neuraminidase (NA) in influenza vaccines. The new kit is poised to help improve ...