However, the impacts of neddylation inhibition on VSMCs and neointimal hyperplasia have not been studied. In our present study, we have shown that MLN4924, a selective inhibitor of NEDD8 ...

“The existence of a novel neddylation inhibitor in early-stage clinical trials further intrigued us to this pathway,” said Dr. Norton. MLN4924 (Pevonedistat) is a small molecule that inhibits ...

Inhibition of neddylation is already being investigated in other tumor types in clinical trials. In pancreatic cancer MLN4924 has also been shown to have an additive effect with cisplatin," says Prof.

Inhibition of neddylation is already being investigated in other tumor types in clinical trials. In pancreatic cancer MLN4924 has also been shown to have an additive effect with cisplatin," says Prof.

The treatment occurs both in the presence (+) and absence (-) of MLN4924, a neddylation inhibitor. Neddylation is a post-translational modification similar to ubiquitination, thus inhibiting the ...

The treatment occurs both in the presence (+) and absence (-) of MLN4924, a neddylation inhibitor. Neddylation is a post-translational modification similar to ubiquitination, thus inhibiting the ...

NAE modulates the level of proteins critical for the regulation of cancer cell growth and survival pathways. Preclinical data show that MLN4924 inhibition of NAE function alters these important cancer ...

The potential utility of blocking NEDDylation has not passed the pharma industry by. Takeda Pharmaceutical already has a NEDD8 activating enzyme inhibitor, MLN4924, in Phase I trials against ...

Professor Yi Sun's team at the Zhejiang University report a functional compensatory effect between the Ube2m-Rbx1 and Ube2f-Sag axes of the neddylation–Cullin-RING ligases (CRLs) system in T reg ...