研究团队首先用neddylation抑制剂MLN4924联合不同代际TKIs（伊马替尼、尼洛替尼、普纳替尼）处理K562细胞，意外发现MLN4924竟使TKIs的细胞毒性"功亏一篑"。这种"帮倒忙"现象在KU812细胞系和小鼠移植瘤模型中均得到验证，而neddylation激活剂VII-31则展现协同效应。

更引人深思的是，虽然Neddylation抑制剂MLN4924能增强肾髓质癌对铂类的敏感性，其作为ccRCC治疗靶点的潜力却从未被系统评估。 为解开这些谜题，研究人员整合了TCGA数据库516例ccRCC患者的转录组和临床数据，通过生物信息学"抽丝剥茧"：首先利用ConsensusClusterPlus进行 ...

Department of Hematology, Oncology and Cancer Immunology, Charité─Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, D-12203 Berlin, Germany ...

Center on Translational Neuroscience, College of Life and Environmental Science, Minzu University of China, Beijing, China MicroRNAs (miRNAs) are small non-coding RNAs with the unique ability to ...

Significant interactors were identified using SAINT scores > 0.70 and FDR < 5%. C) HEK293T cells transfected with empty vector (EV), FLAG-GMCL1 WT, FLAG-GMCL1 BBO, FLAG-GMCL1 WKE_AAA (broadly disrupts ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. The ubiquitin receptor protein DSK2 modulates ...

Contributed by William G. Kaelin Jr., December 9, 2018 (sent for review November 2, 2018; reviewed by Deepak Nijhawan and Charles L. Sawyers) Systems for degrading proteins at will are useful for a ...