Most cells in the human body each contain about six feet of DNA. Yet the nucleus, where DNA is coiled, is no larger than a ...

Learn about Brink Therapeutics as it raises $4 million to go beyond CRISPR with engineered recombinases in CAR T therapy.

Nature, first published on 4 November 1869, is ranked the world s most cited interdisciplinary scientific journal by the Science Edition of the 2010 Journal Citation Reports. Most scientific ...

began with a genome-wide genetic screen based on CRISPR interference (CRISPRi) that systemically reduces the expression of every single gene in the genome of a pluripotent stem cell (PSC ...

To identify MYC-SL targets, we performed a genome-wide CRISPR knock-out screen using an isogenic pair of non-transformed and MYC-driven breast cancer cells. In contrast to other screens, this model is ...

他们的研究成果发表在《Nature Methods》上，为 3D 基因组的研究开辟了新的道路。 研究人员开发了一种基于图像的高通量高内涵筛选平台 ——Perturb-tracing。该平台主要运用了三个关键技术：一是汇集式 CRISPR 筛选（pooled CRISPR screens），能够对众多候选基因进行大 ...

Its simplicity has facilitated large-scale experiments to assess gene functionality across diverse biological contexts, generating extensive datasets that boosted the development of computational ...

This study aims to identify novel biological factors that predict PARPi response in SCLC. Methods: A genome-wide CRISPR-Cas9 knockout (KO) screen was conducted in the SBC-5 SCLC cell line using the ...

Researchers have developed a machine learning model that predicts Cas9 proteins that can be tailored with designer properties for therapeutic use.