Although NR4A (the nuclear receptor subfamily 4 group A) plays an important role in cardiovascular pathophysiology, the expression profile and biological function of NR4A member 1 (NR4A1) in platelets ...

为探究 NR4A1 在颈动脉斑块形成和易损性中的作用，研究发现其通过靶向 Bcat1 激活 ISR 促进斑块易损，为治疗提供新靶点。 在心血管疾病的舞台上，颈动脉粥样硬化斑块的破裂堪称 “定时炸弹”，它是缺血性中风的主要诱因之一，严重威胁着人类健康。一直以来 ...

Department of Veterinary Physiology and Pharmacology, College of Veterinary Medicine, Texas A&M University, College Station, Texas 77843 , United States ...

在体内实验中，MCM8 沉默后，肿瘤生长明显受到抑制。进一步研究揭示，MCM8 通过与转录因子 NR4A1 相互作用，调节 E2F1 的转录，进而影响肾癌细胞的有氧糖酵解过程和细胞行为。这一研究成果发表在《Cell Biology and Toxicology》杂志上，为肾癌的治疗提供了新的潜在 ...

Results Immunofluorescence and cytometry suggested entheseal resident CD4+ and CD8+ T cells with a resident memory phenotype (CD69+/CD45RA-) and tissue residency gene transcripts (higher NR4A1/AhR and ...

Objectives In this study, we employ a multiomic approach to identify major cell types and subsets, and their transcriptomic profiles within the infrapatellar fat pad (IFP), and to determine ...

(A) PGE2 costimulates TNF-induced expression of select inflammatory genes such as IL-1 and Notch pathway genes and neutrophil chemokines by inducing transcription factors including CEBP, AP-1 and ...

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Background: Domestication of wild boars into local and intensive pig breeds has driven adaptive genomic changes, resulting in significant phenotypic differences in intestinal immune function. The ...