The research group plans to further improve the integration of the techniques of cryo-EM with X-ray imaging and diffraction at X-ray free-electron laser and synchrotron ... Intelligent biosensor ...

Cryo-EM techniques, such as single particle analysis (SPA), now enable structural identification of biomolecules at resolutions previously only possible with X-ray crystallography. Cryo-EM opens up ...

qFit protein is a tool that automatically identifies alternative conformations based on a high-resolution density map (generally better than ~2 Å) and a well-refined single-conformer structure ...

Technical advances in cryo-electron microscopy (cryo-EM) are revolutionizing structural biology, as samples that could previously only be studied by X-ray crystallography or nuclear magnetic resonance ...

When compared to other structural biology techniques, such as NMR spectroscopy and X-ray crystallography, cryo EM has distinct advantages and limitations. NMR spectroscopy is well-suited for studying ...

Researchers at Tokyo Tech have discovered hidden chemical order of the Mo and Nb atoms in disordered Ba 7 Nb 4 MoO 20, by combining state-of-the-art techniques, including resonant X-ray diffraction ...

The main techniques used in structural biology include X-ray crystallography, nuclear magnetic resonance (NMR) spectroscopy and cryogenic electron microscopy (cryo-EM), which are usually complemented ...

However, for about half of the NMR/X-ray pairs we observe DP scores and RDC Q factors indicating that the AlphaFold models fit the NMR data a bit better than the corresponding X-ray crystal structures ...

Hyderabad: A cutting-edge facility for cryo-electron microscopy was inaugurated by Dr Shekhar Mande, ... NMR spectroscopy and X-ray diffraction facilities at CCMB, ...

Dr Rajan Sankaranarayanan, an eminent structural biologist at CCMB, said that the modern cryo-electron microscopy facility is expected to help us view the functioning of several molecular machines ...