Olink proximity extension assay panels were used to measure 29 proteins associated with the NLRP3 inflammasome pathway. Six of these proteins were associated with recurrent cardiovascular events ...

Recent studies suggest that methyltransferase-like 3 (METTL3), a critical RNA methyltransferase, may regulate the nucleotide-binding oligomerized structural domain-like receptor protein 3 (NLRP3) ...

Among various immune and inflammatory reactions, researchers have increasingly focused on the inflammasome, a complex of proteins. The initiation and activation of the inflammasome are intricately ...

The researchers found that the activation of NLRP3 and AIM2 inflammasomes—proteins in immune cells that detect threats and trigger a response—is a key factor in severe inflammatory responses ...

The new model, called BaseFold, enables more reliable 3D structure predictions for larger and more complex proteins and, according to the company, is “poised to greatly accelerate AI-based drug ...

While most studies focus on the entire protein structure, they often overlook the local structure of protein pockets which play a vital role in DTA due to their direct interaction with drugs. At the ...

Credit: Photo realized Courtesy of DIFFERENT- Restaurant in the Darkness. Source IPC PAS, Grzegorz Krzyzewski Researchers have uncovered the 3D structure of RBP3, a key protein in vision, revealing ...

MULAN uses the pre-trained base PLM and has the Structure Adapter – a module we introduce to incorporate the knowledge about the 3D protein structure. Our model uses ESM-2 architecture, initializing ...

While the vast number of protein powders on the market can make the task of choosing one daunting, it also means there are probably several options that will be a good fit for you. Protein powders ...