The new model, called BaseFold, enables more reliable 3D structure predictions for larger and more complex proteins and, according to the company, is “poised to greatly accelerate AI-based drug ...

While most studies focus on the entire protein structure, they often overlook the local structure of protein pockets which play a vital role in DTA due to their direct interaction with drugs. At the ...

The latest version of Google DeepMind and Isomorphic Labs’ AlphaFold model can predict the structure and relationships not only of proteins, but “all of life’s molecules”, according to its ...

The researchers found that the activation of NLRP3 and AIM2 inflammasomes — proteins in immune cells that detect threats and trigger a response — is a key factor in severe inflammatory respons ...

NLRP3 激活机制一直成谜，为探究其奥秘，研究人员以表达特定 NLRP3 突变体的细胞系为模型开展研究。结果发现 NLRP3 棕榈酰化促进其液 - 液相分离（LLPS），驱动炎症小体激活。该研究为理解 NLRP3 激活提供新视角。 炎症，就像是身体里的一场 “小战争”，是身体 ...

This occurred in part by reducing signaling from the NLRP3 "inflammasome" protein, which plays a necessary role in vascular calcification. "These results are of particular importance because they ...