A new study from scientists at the Buck Institute for Research on Aging has revealed a surprising player in the battle ...

Researchers have uncovered how the breakdown of glycogen may protect the brain from neurodegeneration and Alzheimer's.

Research uncovered how glycogen metabolism in neurons impacts neurodegenerative diseases like Alzheimer's. Disruption in this ...

在生理层面上，这种辅酶特异性转换可能使SpGdh1在NADPH匮乏时转向NADH利用，维持氮同化功能；在应用层面，该发现为设计辅酶偏好性可调的工业酶提供了理论依据。未来研究将聚焦于鉴定调控SpGdh1磷酸化的上游激酶/ ...

Scientists have uncovered a surprising sugar-related mechanism inside brain cells that could transform how we fight Alzheimer ...

NADPH oxidase 4 (NOX4) is a reactive oxygen species (ROS) producing NADPH oxidase that regulates redox homeostasis in diverse insulin-sensitive cell types. In particular, NOX4-derived ROS is a key ...

为解决左炔诺孕酮合成中关键中间体(13r,17s)-乙基二醇生物转化效率低的问题，中国科学院上海有机化学研究所团队鉴定了酿酒酵母as2.346中新型nadph依赖性羰基还原酶assdr1。通过基因编辑、亚细胞定位分析和蛋白质工程，发现assdr1的线粒体外定位是其高效催化活性的关键，突变体i180a使产量提升47.88% ...

Get Instant Summarized Text (Gist) A peptide-bridged fusion oxidoreductase enables electrostatic channeling of NADP +, greatly reducing NADPH consumption and enhancing catalytic efficiency.The R10 ...

Background Inhibition of the nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (NOX) pathway improves the neurological outcome in the transient middle cerebral artery occlusion (tMCAO) ...

Dysregulated reactive oxygen species (ROS) are implicated in various diseases, positioning NADPH oxidase enzymes (NOXs) as attractive therapeutic targets. However, progress in tool compound discovery ...

Discover how photosynthesis works, the role of chlorophyll, and why this natural process is essential for life on ...

生活中，我们应该都听过“运动对健康有益”的说法。说实话，运动不仅能锻炼肌肉，还可以帮助增强心血管系统、代谢功能，甚至能够延缓衰老对个体的影响。你知道吗？有研究曾发现，运动可以促进骨骼肌产生更多的NADPH氧化酶（NOX4），降低肌肉萎缩、糖尿病等衰老 ...