The myosin cross-bridge binds to ATP, and then releases its attached actin filament. The cross-bridge then hydrolyses the ATP, and primes itself in preparation for a productive working stroke.

Muscle contraction involves the cyclic interaction of the myosin cross-bridges with the actin filament, which is coupled to steps in the hydrolysis of ATP1. While bound to actin each cross-bridge ...

Myosin makes the moves to keep cell processes humming along by Leah Shaffer, Washington University School of Medicine in St. Louis edited by Stephanie Baum , reviewed by Robert Egan ...

Myosin-5 working stroke and walking on F-actin. (Credit: Klebl et al., 2024) The past years has seen many refinements in cryo-EM, with previously quite manual approaches shifting to microfluidics ...

PKG activates myosin phosphatase, leading to the release of calcium ion stores from the smooth muscle cells, relaxing them. COVID-19 can cause acute respiratory distress syndrome (ARDS) in severe ...

Excess myosin actin cross-bridge formation and dysregulation of the super-relaxed state are mechanistic hallmarks of HCM. CAMZYOS shifts the overall myosin population towards an energy-sparing ...

Cardiac Myosin Inhibitor Gets FDA's Blessing for Obstructive HCM — First-in-class mavacamten will be subject to REMS, however by Nicole Lou , Senior Staff Writer, MedPage Today April 29, 2022 ...

Patients with obstructive hypertrophic cardiomyopathy (HCM) who took the myosin inhibitor aficamten (Cytokinetics) showed major improvements in heart failure (HF) symptoms, functional capacity ...