It also has broader implications for understanding condensation of other proteins that move under the influence of myosin motors. /Public Release. This material from the originating ...

Myosin VI achieves this by using a 180° lever arm swing and ... T., Arata, T. & Oosawa, F. Sliding distance of actin filament induced by a myosin crossbridge during one ATP hydrolysis cycle ...

Background—Hypertension (HTN) causes concentric left ventricular remodeling, defined as an increased relative wall thickness or overt left ventricular hypertrophy, and associated diastolic dysfunct ...

BACKGROUND: Modulating myosin function is a novel therapeutic approach in patients with cardiomyopathy. Danicamtiv is a novel myosin activator with promising preclinical data that is currently in ...

Myosin motors transduce ATP free energy into mechanical work. Transduction models allocate specific functions to motor structural domains beginning with ATP hydrolysis in the active site and ending in ...

Background— The left ventricles of both rabbits and humans express predominantly β-myosin heavy chain (MHC). Transgenic (TG) rabbits expressing 40% α-MHC are protected against tachycardia-induced ...

Catch force in molluscan smooth muscle requires little, if any, energy input and is controlled by the phosphorylation state of the thick filament-associated mini-titin, twitchin. The kinetic ...

Laser Trap Studies Using Unregulated Actin Filaments. V actin in the motility assay is the result of many myosin molecules interacting simultaneously with a given thin filament. How regulation is ...

Force generation in striated muscle results from myosin cyclically interacting with actin, a Ca 2+-regulated process mediated by the actin-associated regulatory proteins, troponin (Tn) and tropomyosin ...