The five muscarinic acetylcholine receptors (mAChRs) are prototypical class A G protein-coupled receptors (GPCRs). mAChRs regulate many fundamental functions of the central and peripheral nervous ...

The cholinergic system has two types of receptors: muscarinic and nicotinic. Muscarinic receptors function in the peripheral and central nervous systems and are present in various organs ...

Muscarinic receptors are central to brain function and validated as drug targets in psychosis and cognitive disorders. Sosei Heptares has discovered selective muscarinic M4, M1 and M1/M4 dual ...

Long-acting muscarinic antagonists, as add-on therapy to inhaled corticosteroids, improve lung function parameters and reduce ...

Schizophrenia is currently treated with older medications with limited efficacy and troublesome side effects that lead many patients to stop taking them. The FDA has approved a novel Bristol Myers ...

Cisbio Bioassays, has announced that it has expanded its catalogue of Tag-lite® fluorescent ligands, used for the investigation and screening of G-protein coupled receptor (GPCR) activity, to 43 ...

There, muscarinic agonists depress transmission at excitatory ... point to a key role for this receptor in motor function. “However, there is also some reason to believe that it could be important in ...