ACh is produced by the enzyme choline acetyltransferase and its actions are mediated through two types of acetylcholine receptors (AChRs) — the G protein-coupled muscarinic AChRs and the ...

This valuable study shows that locomotion-related modulations in the mouse visual cortex are not uniform but primarily affect neurons in muscarinic receptor-negative patches, which receive projections ...

The drug, a unique combo of xanomeline and trospium chloride targeting M1/M4 muscarinic receptors, failed to pass the finish line in the ARISE Phase III trial. The study aimed to validate its use as ...

The new data – from the ARISE trial – found that Cobenfy wasn't statistically better than placebo at improving the widely ...

Ltd. have synthesized azetidine-containing compounds acting as muscarinic M4 receptor positive allosteric modulators (PAMs) reported to be useful for the treatment of Alzheimer’s disease, asthma, pain ...

The M1/M4 muscarinic receptor agonist is vying to be the first drug to reach the market for schizophrenia with a new mechanism of action in decades. It is also in phase 3 clinical testing as an ...

Indacaterol is an inhaled long-acting beta-2 adrenergic agonist used to relax bronchial smooth muscle and improve symptoms ...

Cobenfy is an oral small molecule designed to target and block muscarinic receptors in the brain. The drug, formulated as a twice-daily capsule, selectively targets the M1 and M4 receptors without ...

Vitamin D deficiency directly causes erectile dysfunction by increasing superoxide and reducing protective SLPI levels, as ...

Non-clinical studies have demonstrated that omadacycline inhibits the binding of the neurotransmitter carbamylcholine to the M2 subtype of the muscarinic acetylcholine receptor, while remaining ...