Muscarinic acetylcholine receptors (mAChRs), M 1 –M 5, regulate the activity of numerous fundamental central and peripheral functions. The lack of small-molecule ligands that can block or ...

Bodick NC, Offen WW, Levey AI, et al. Effects of xanomeline, a selective muscarinic receptor agonist, on cognitive function and behavioral symptoms in Alzheimer disease. Arch Neurol 1997;54:465 ...

Cisbio Bioassays, has announced that it has expanded its catalogue of Tag-lite® fluorescent ligands, used for the investigation and screening of G-protein coupled receptor (GPCR) activity, to 43 ...

The cholinergic system has two types of receptors: muscarinic and nicotinic. Muscarinic receptors function in the peripheral and central nervous systems and are present in various organs ...

Muscarinic receptors are central to brain function and validated as drug targets in psychosis and cognitive disorders. Sosei Heptares has discovered selective muscarinic M4, M1 and M1/M4 dual ...

Ultimately, the team identified M1R (muscarinic acetylcholine receptor 1 subtype) as the target for clemastine and other anti-muscarinic ... In these mice, there was significant remyelination, axons ...

G-proteins are important cell signaling molecules, and researchers can investigate cell function in living ... derived from the human muscarinic receptor hM3 by two point mutations.

The muscarinic receptors on brain cells bind with the brain chemical acetylcholine, which is the target of certain cognition-related treatments for Alzheimer’s disease. In studies that Karuna ...

There, muscarinic agonists depress transmission at excitatory glutamatergic synapses ... including the M4 knockout mouse, point to a key role for this receptor in motor function. “However, there is ...

BOSTON--(BUSINESS WIRE)--Karuna Pharmaceuticals, focused on targeting muscarinic receptors for the treatment of disorders marked by psychosis and cognitive impairment, today announced the ...