Introduction: The cholinergic anti-inflammatory pathway regulates immune responses through the alpha7 nicotinic acetylcholine receptor (α7nAChR), found in neurons, macrophages, and monocytes. α7nAChR ...

Muscarinic receptors are involved with neurotransmission via acetylcholine and glutamate ... Leaving out activity against M2 and M3 receptors could also improve the safety and tolerability ...

A Vanderbilt University patent discloses new muscarinic M4 receptor positive allosteric modulators and agonists reported to be useful for the treatment of Alzheimer’s disease, pain, schizophrenia, ...

1 Department of Neurology, Wuhan No. 1 Hospital, Wuhan, China 2 The First Clinical Medical Institute, Hubei University of Chinese Medicine, Wuhan, China Introduction/Aims: Myasthenia Gravis (MG) is a ...

Muscarinic (M ... neural transmission; M2 receptors, located on the postganglion endings of the cholinergic fibers, with the role of limiting further acetylcholine release from the postganglion ...

Correspondence to Dr Peter Ong, Department of Cardiology, Robert-Bosch Krankenhaus, Auerbachstr. 110, 70376 Stuttgart, Germany; Peter.Ong{at}rbk.de ...

Corticotropin-releasing factor 1 receptors; M1/2R, Muscarinic acetylcholine 1 and 2 receptors; nAchR, Nicotinic acetylcholine receptors; OXTR, Oxytocin receptors; OX1R, Orexin 1 receptors; SSRIs, ...

These compounds are: NBI-1117570 (a dual M1 / M4 agonist) NBI-1117567 (an M1-preferring agonist) NBI-1117569 (an M4-preferring agonist) Nxera and Neurocrine entered a collaboration and licensing ...

These authors contributed equally to this work.

Faculty of Pharmacy and Research and Innovation Hub, Alamein International University, Alamein, Matrouh 51718, Egypt Department of Pharmacology and Toxicology, Faculty of Pharmacy, Alexandria ...