Muscarinic receptors are involved with neurotransmission via acetylcholine and glutamate ... Leaving out activity against M2 and M3 receptors could also improve the safety and tolerability ...

3) Bristol Myers Squibb's Cobenfy (KarXT; xanomeline and trospium chloride), a dual M1/M4 muscarinic acetylcholine receptor agonist for schizophrenia and psychosis related to Alzheimer's disease.

and acetylcholine esterase receptor antibody (AChR-Ab; orange triangles) from baseline during cycle 1 of the ADAPT trial of efgartigimod (at a dose of 10 mg per kilogram of body weight per week ...

APD = Antipsychotic background drug; PANSS = Positive and Negative Syndrome Scale; PSP = Personal and Social Performance Scale; CGI-S = Clinical Global Impressions Severity Scale; mITT = modified ...