The CeraVe story began in 2005 after experts noticed that many skin conditions such as acne, eczema, psoriasis, and dry skin ...

Recent studies showed an unexpected complexity of extracellular vesicle (EV) biogenesis pathways. We previously found evidence that human colorectal cancer cells in vivo release large multivesicular ...

Here, we identified that phosphatidylinositol-3-phosphate (PI3P) mediates Arc capsid assembly and secretion through the endosomal–multivesicular body (MVB) pathway. Indeed, reconstituted Arc protein ...

Learn all about the human body's many systems and some of its individual organs, both vital and vestigial. When you purchase through links on our site, we may earn an affiliate commission. Here ...

BACKGROUND: Cardiac hypertrophy and subsequent heart failure impose a considerable burden on public health worldwide. Impaired protein degradation, especially endo-lysosome-mediated degradation of ...

Charged Multivesicular Body Protein 2B Overexpression Impairs Autophagic Flux in Cardiomyocytes, Leading to Myocardial Vulnerability to Ischemia/Reperfusion. We evaluated the functional relationship ...

MVB, multivesicular body; PVC, prevacuolar compartment; ER, endoplasmic reticulum; TGN, trans-Golgi network. In this mini review, we summarize the recent advances in research into the MVB and ...

Multivesicular bodies deliver long-range retrograde nerve growth factor (NGF) signals and serve as essential signaling and sorting platforms in the cell soma, and multivesicular body (MVB) cargoes ...