In addition to its long-studied presence in the cytoplasm, actin is also found in the nuclei of eukaryotic cells. The function and form (monomer, filament, or noncanonical oligomer) of nuclear actin ...

Here, we report the biochemical characterization of human cytoskeletal γ-actin carrying mutation E334Q, a mutation that leads to a hitherto unspecified non-muscle actinopathy. Following expression, ...

Together our studies reveal that PGs play an important role in limiting the level of nucleolar actin and regulating its form–G-actin vs. C4 G-actin and monomeric vs. polymeric actin (AC15). We ...

These studies unraveled a cooperation with ADF/Cofilin and Twinfilin in F-actin disassembly, a nucleotide exchange activity on globular actin monomers (G-actin) that is required for F-actin assembly ...

Asgard profilins were demonstrated to regulate actin filament nucleation. Here, we identify actin filament severing, capping, annealing and bundling, and monomer sequestration activities by gelsolin ...

Figure 2: Classic model of F-actin network regulation. As the filament elongation rate is directly proportional to the concentration of polymerizable monomers, the rate that F-actin is recycled ...

Thymosin-β4 (Tβ4) sequesters actin monomers to help maintain the high concentrations of unpolymerized actin in higher eukaryotic cells. Despite more than two decades of research investigating the ...

Both Republicans and Democrats have decided, in poker lingo, to go all-in on the same hand, the looming set of mandatory across-the-board cuts known as the sequester. Both sides agree it is bad ...

It is unclear whether cofilin contributes to stimulus-induced actin filament assembly by supplying actin monomers for polymerization or by creating free barbed ends through its severing activity. By ...

The WH2 (Wiscott–Aldridge syndrome protein homology domain 2) repeat is an actin interacting motif found in monomer sequestering and filament assembly proteins. We have stabilized the prototypical WH2 ...