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单细胞分辨率下小鼠早期器官发生期全胚胎数字重建揭示原基决定区 ...
通过开发SEU-3D可视化平台,研究者实现了单细胞分辨率的三维数字胚胎重建,该平台包含虚拟全mount原位杂交(vWMISH)、可定制视角的虚拟切片和Flatmap模块等功能。数字胚胎清晰展示了从E7.5到E8.0的形态学变化过程,如尿囊芽和节点的出现、心脏新月形结构的形成等。
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