Receptor pharmacology is the study of the interactions of receptors with drugs/pharmaceuticals and other xenobiotics. A basic tenet of receptor pharmacology is that a drug’s effect is directly ...

Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are a group of drugs used to treat type 2 diabetes and sometimes obesity. GLP-1 RAs are very effective at lowering blood sugar levels.

This is important because at higher levels, cortisol may also bind to mineralocorticoid receptors. This may explain why many synthetic glucocorticoids have mineralocorticoid activity [2].

G protein-coupled receptors (GPCRs) are integral membrane proteins with seven membrane-spanning helices. Upon binding to a ligand – which can range from small molecules like cyclic AMP to ...

Bayer has filed its mineralocorticoid receptor antagonist finerenone as a treatment heart failure in the EU, but can it meet blockbuster sales hopes?

At the time the licensing agreement was signed in October 2023, ocedurenone – an oral non-steroidal mineralocorticoid receptor antagonist (nsMRA) – was being tested in a phase 3 trial in ...