Scientists produce human DNase1 in yeast for the first time, opening doors to wider clinical use and easier manufacturing.

The protein DNase1 is one of the oldest biological agents in history. It has been on the market since 1958 and is now used, ...

2 Its diagnosis is therefore often delayed and patient management is challenging. Therefore, we developed a novel, clinically relevant pig model of autologous coronary microthrombi (MT)-induced MINOCA ...

The protein DNase1 is one of the oldest biological agents in history: It has been on the market since 1958 and is now used, among other things, to treat cystic fibrosis. However, it takes considerable ...

The protein DNase1 is one of the oldest biological agents in history: It has been on the market since 1958 and is now used, among other things, to treat cystic fibrosis.

In the event of sepsis but also a severe infection with SARS-CoV-2, there is a pathologically increased formation of NETs and microthrombi that contain high levels of NET components. "It could be ...

In diseases like sepsis or COVID-19, NETs can become overactive and form dangerous microthrombi. “It could be useful to use DNase1 to better dissolve these microthrombi that contain DNA,” said ...

This results in a contradictory state of hypercoagulability with systemic microthrombi simultaneously occurring with systemic hemorrhage. The clinical manifestations, treatment, and outcome are ...

In the event of sepsis but also a severe infection with SARS-CoV-2, there is a pathologically increased formation of NETs and microthrombi that contain high levels of NET components. "It could be ...