Scientists produce human DNase1 in yeast for the first time, opening doors to wider clinical use and easier manufacturing.

The protein DNase1 is one of the oldest biological agents in history. It has been on the market since 1958 and is now used, ...

The protein DNase1 is one of the oldest biological agents in history: It has been on the market since 1958 and is now used, among other things, to treat cystic fibrosis.

In the event of sepsis but also a severe infection with SARS-CoV-2, there is a pathologically increased formation of NETs and microthrombi that contain high levels of NET components. "It could be ...

This results in a contradictory state of hypercoagulability with systemic microthrombi simultaneously occurring with systemic hemorrhage. The clinical manifestations, treatment, and outcome are ...

In the event of sepsis but also a severe infection with SARS-CoV-2, there is a pathologically increased formation of NETs and microthrombi that contain high levels of NET components.

Other clots in small blood vessels (these clots are known as "microthrombi") have also been found in COVID-19 patients. (See below for details.) 4. What are the overlapping clinical features of ...

In diseases like sepsis or COVID-19, NETs can become overactive and form dangerous microthrombi. “It could be useful to use DNase1 to better dissolve these microthrombi that contain DNA,” said ...