Immune cells in the brain called microglia can partially break down large amyloid plaques characteristic of Alzheimer’s disease by latching on to them, forming a sort of external stomach and releasing ...

Microglia degrade plaques, but they are also known to contribute to the formation of plaques. This paradox was intriguing, and the researchers wondered if digestive exophagy could play a role in ...

"Some hypothesized that microglia cleared amyloid-β (Aβ) plaques – the biological signature of Alzheimer's disease – from the brain, while others were convinced that microglia were involved ...

“It leads to interesting questions about the interplay [between microglia and neurons],” he said. Tahirovic and colleagues acknowledge the model’s limitations. Even so, they reasoned that if excessive ...

Image Credit: Axol Bioscience Ltd To evaluate the functional performance of the axoCells Microglia, Axol conducted various assays, such as phagocytosis, chemotaxis, and cytokine release ...

Immune cells in the brain called microglia can partially break down large amyloid plaques characteristic of Alzheimer's disease by latching on to them, forming a sort of external stomach and ...

Because immune dendritic cells express CD83 when fighting pathogens, first author Readhead searched for signs of infection in tissue from donors who had CD83+ microglia. The donors participated in the ...

Defective microglia also contribute to brain inflammation and the accumulation of amyloid beta plaques characteristic of the disease. In mice with Alzheimer's-like disease, inhaling xenon gas was ...