Although several companies sell tissue microarrays, not all of them are suited for every application. “One of the critical issues is the quality of the tissues used,” says Brown.

methods will be developed so that LCM can be coupled to microarray-based analysis, allowing gene expression to be comprehensively profiled in small numbers of cells or even in single cells.

One way they do this is to use a DNA microarray to determine the expression ... is isolated from the samples. The mRNA is color-coded with fluorescent tags and used to make a DNA copy (the mRNA ...