资讯

Nature9 年
p53 regulates the mevalonate pathway in human glioblastoma multiforme
The mevalonate (MVA) pathway is an important metabolic pathway implicated in multiple aspects of tumorigenesis. In this study, we provided evidence that p53 induces the expression of a group of ...
Nature9 年
Control of the innate immune response by the mevalonate pathway
Deficiency in mevalonate kinase (MVK ... Pggt1b or a constitutively active form of p110δ (E1121K) 23. Expression of E1121K, but not wild-type p110δ, completely abrogated LPS-induced IL-1β ...