In this Review, Turnbaugh and colleagues discuss several mechanisms by which the human gut microbiome affects the metabolism of xenobiotics, including drugs and dietary compounds, and explore how ...

Drug metabolism is the term used to describe the biotransformation of pharmaceutical substances in the body so that they can be eliminated more easily. The majority of metabolic processes that ...

Most major drugs are effective in only 25 to 60 percent of patients, 1 and more than 2 million cases of adverse drug reactions occur annually in the United States, including 100,000 deaths. 2 Such ...

Safety Assessment of Drug Metabolites January 15, 2010. By Graham A. McGibbon, PhD , Pranas Japertas, PhD and Sanjivanjit K Bhal, PhD . January 15, 2010 ...

Additionally, recombinant P450s (E. coli expressed recombinant enzymes) can be employed to determine the specific enzymes involved in drug metabolism (e.g., CYP1A2, 2C8, 2C9, 2C19, and CYP3A4).

The discovery of disproportionate drug metabolites late in drug development can potentially cause development and marketing delays,” stated the guidance. Generally, metabolites identified only in ...

Codexis®, Inc. has introduced the Codex™ MicroCyp Plate, a research productivity tool which can be used by pharmaceutical companies to identify and synthesize drug metabolites and novel drug lead ...