Then, the potential application of some molecules as diagnostic markers or therapeutic targets for treatment is reviewed. Finally, the methods that are applied to deplete macrophages are discussed.

In contrast, there was a reduction in pro-inflammatory and pro-oxidant markers, including CD80, CD81, IL-6R, IL-12, TNF-α, MDA, and NO, which act as immunostimulatory macromolecules (P < 0.05).

SLAMF8 knockdown in THP-1 cells reduced M1 macrophage markers (CD86, iNOS, NLRP3) and decreased inflammatory cytokines (IL-1β, IL-6, TNF-α). Co-culture with M1 macrophage supernatant after SLAMF8 ...

The transition of MDMs from M1 to M2 phenotype was evaluated through gene expression and protein synthesis of M2 macrophage markers, namely scavenger receptors (CD163 and CD204), and mannose ...

smu.edu.cn, baixc15{at}smu.edu.cn Objectives To investigate the roles and regulatory mechanisms of synovial macrophages and their polarisation in the development of osteoarthritis (OA). Methods ...

Bone marrow derived macrophages were prepared and polarised to classic (M1) or alternative (M2) activation states. Markers for macrophage phenotype were measured using quantitative RT-PCR. Results ...

This study provides useful information by identifying the cell type (macrophages) in synovial tissues involved in the pathogenesis of post-traumatic osteoarthritis (OA) and clarifying distinct ...

School of Pharmacy, Liaoning University of Traditional Chinese Medicine, Dalian 116600, China School of Pharmacy, Liaoning University of Traditional Chinese Medicine, Dalian 116600, China Shenyang Key ...