In a recent study published in the Genes & Diseases journal, researchers from Chongqing Medical University, Western Institute of Digital-Intelligent Medicine, and the University of Chicago Medical ...

为探究 MCT4 在胃癌中的作用，研究人员经多实验研究发现其影响胃癌转移和免疫微环境，意义重大。 《Journal of Translational Medicine》上发表的一项研究，为我们揭示了胃癌研究领域的新发现。胃癌，这个全球范围内癌症相关死亡的 “第四大杀手”，严重威胁着 ...

However, the metabolic cues that direct and support macrophage functions in the skin are poorly understood. Here, we show that during sterile skin inflammation, the epidermis and macrophages uniquely ...

Metabolically, glycolytic CAFs support the energy needs of oxidative (OXPHOS) carcinoma cells. Upregulation of the monocarboxylate transporter 4 (MCT4) and downregulation of isocitrate dehydrogenase ...

Moreover, in preclinical models, LKB1 mutant tumors showed enhanced glycolysis and upregulation of MCT4 expression in a variety of human and murine cell lines. Deletion of MCT4 dramatically reduced ...

Monocarboxylate transporter 4 (MCT4), encoded by SLC16A3 gene, is a potential biomarker for bladder cancer because of its crucial role in the lactate efflux in the aerobic glycolysis process. We aimed ...

Lactate export during glycolysis is crucial for continued proliferation of many cancer cells—part ... Here, we show that EBV infection of B lymphocytes directly promotes temporal induction of MCT1 and ...