Tumor cells increase their glucose consumption through aerobic glycolysis to manufacture the necessary biomass required for proliferation, commonly known as the Warburg effect. Accumulating evidences ...

Department of Pharmaceutics, School of Pharmacy, Fudan University, Shanghai 201203, China Key Laboratory of Smart Drug Delivery, Ministry of Education, Fudan University, Shanghai 201203, China State ...

针对三阴性乳腺癌（TNBC）缺乏有效靶点的临床难题，北京大学团队发现肿瘤源性唾液酸化IgG（SIA-IgG）通过激活整合素α6β4-FAK-AKT-HIF-1α-MCT4和CD44-MCT1双通路，重编程糖酵解代谢促进TNBC进展。该研究揭示SIA-IgG可作为TNBC的新型预后标志物和靶向治疗靶点，相关成果 ...