The three-signal paradigm tries to capture how the innate immune system instructs adaptive immune responses in three well-defined actions: (1) presentation of antigenic peptides in the context of MHC ...

Let’s get this part out of the way first: Trail cameras are a pain. Batteries die, SD cards get corrupted, settings get messed up, and squirrels trigger thousands of useless images. So why would you ...

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Oxidative Stress: Neuropathy, Excitability, and Neurodegeneration.

Astragalin therapy resulted in the upregulation of caspases, PARP, Bax, Bad, and Fas level, and downregulation of Bcl-xl and Bcl-2. Furthermore, the MAPK pathway was deactivated and LPS was inhibited ...

1 Department of Gastroenterology and Hepatology, Academic Medical Centre, Amsterdam, the Netherlands 2 Department of Experimental Internal Medicine, Academic Medical Centre, Amsterdam, the Netherlands ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. mTOR plays a pivotal role in cancer growth ...

TCM Regulating Metabolic Diseases Key Laboratory of Sichuan Province, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu 610075, Sichuan, China Oncology Teaching and Research ...

Correspondence to Maurizio Rolando, Ocular Surface Unit, ISPRE Genova, Genoa, Italy; maurizio.rolando{at}gmail.com Dry eye disease (DED) is a growing public health concern affecting quality of life ...