Moreover, application of the muscarinic agonist carbachol or the physiological M3-R ligand acetylcholine resulted in increased odour-induced responses in OSNs. To identify the mechanism ...

The M3 muscarinic receptor–T4 lysozyme fusion ... using the baculovirus system in the presence of 1 μM atropine. M3 receptors expressed in Sf9 cells are known to exhibit functional and ...

Muscarinic receptors are important drug targets in psychosis ... effects while avoiding the unwanted activation of M2 and M3 and its associated side effects. Our selective muscarinic agonist ...

(“Neurocrine”; Nasdaq: NBIX), a leading neuroscience-focused biopharmaceutical company, has confirmed its plans to evaluate two new muscarinic agonist candidates in Phase 1 first-in-human ...

Both NBI-1117569 (an M4-preferring agonist) and NBI-1117567 (an M1-preferring agonist) are investigational, oral, muscarinic agonists discovered by Sosei Heptares that may have the potential to treat ...

An End of Phase 2 meeting for NBI-1117568 (NBI-’568, an oral, muscarinic M4 selective agonist) has been completed with the US Food & Drug Administration and Neurocrine reiterated its intentions to ...