For decades, researchers have wondered why some people with risky gene variants go on to develop Parkinson’s disease, while ...

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A video of a Golden Retriever named Mika shows a dog’s different kinds of sighs while also explaining the possible reasons behind each. The compilation documented Mika’s various sighs and ...

3 Different types of damage that can induce a CASM response As cells are exposed to many ... In the absence of ATG5, ALIX exhibits a strong affinity for ATG12-ATG3, impairing its recruitment to ...

we focus some of our attention on lysosome resilience and responses in these cell types; however, the mechanisms described here have been found in various other cell types where they equally apply.

Specialized secretory lysosomes and lysosome-related organelles exist in some cell types. Lysosomes may also fuse with phagosomes and autophagosomes. Some phagocytosed pathogens can prevent or ...

Led by postdoctoral fellow Golam Saffi and former master’s student Lydia To, the team found that INPP4B exerts its tumour-promoting effects via lysosomes ... such as acting as a tumour suppressor in ...

The structure and function of lysosomes has captured the increasing attention of cellular biologists and clinical investigators. 1 These membrane-bound intracellular bags of antibacterial ...

to test the impact of LRRK2 genetic and pharmacological perturbations on lysosomal degradative activity in these specialized cell types. Our results revealed an inverse relationship between LRRK2 ...

Tyrosinase is regarded as an important biomarker of melanoma cancer, and its metabolism is closely related to some severe skin diseases ... Notably, because of the tyrosinase deficiency in normal ...

Key Laboratory of Optic-electric Sensing and Analytical Chemistry for Life Science, MOE; Shandong Key Laboratory of Biochemical Analysis; Key Laboratory of Analytical Chemistry for Life Science in ...

Leucine-rich repeat kinase 2 (LRRK2) variants associated with Parkinson’s disease (PD) and Crohn’s disease lead to increased phosphorylation of its Rab substrates. While it has been recently shown ...